الانتقال الى المحتوى الأساسي
23-جمادى الآخرة-1447 هـ
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
معهد الجينوم الطبي
تفاصيل الوثيقة
نوع الوثيقة
:
مقال في مجلة دورية
عنوان الوثيقة
:
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
لغة الوثيقة
:
الانجليزية
المستخلص
:
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopic analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol. Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology as well as oncologic processes.
ردمد
:
103-390
اسم الدورية
:
International journal of molecular sciences
المجلد
:
18
العدد
:
1
سنة النشر
:
1438 هـ
2017 م
نوع المقالة
:
مقالة علمية
تاريخ الاضافة على الموقع
:
Sunday, May 28, 2017
الباحثون
اسم الباحث (عربي)
اسم الباحث (انجليزي)
نوع الباحث
المرتبة العلمية
البريد الالكتروني
Rotoli Deborah
Deborah, Rotoli
باحث رئيسي
دكتوراه
Pérez-Rodríguez Natalia Dolores
Natalia Dolores, Pérez-Rodríguez
باحث
دكتوراه
Morales Manuel
Manuel, Morales
باحث
دكتوراه
Maeso María del Carmen
María del Carmen, Maeso
باحث
دكتوراه
Ávila Julio
Julio, Ávila
باحث
دكتوراه
Mobasheri Ali
Ali, Mobasheri
باحث
دكتوراه
الملفات
اسم الملف
النوع
الوصف
40792.pdf
pdf
الرجوع إلى صفحة الأبحاث