الانتقال الى المحتوى الأساسي
23-جمادى الآخرة-1447 هـ
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
معهد الجينوم الطبي
تفاصيل الوثيقة
نوع الوثيقة
:
مقال في مجلة دورية
عنوان الوثيقة
:
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
لغة الوثيقة
:
الانجليزية
المستخلص
:
Motivation: Sumoylation is a posttranslational modification (PTM) process, in which small ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protein. It is critical to many different biological processes such as replicating genome, expressing gene, localizing and stabilizing proteins; unfortunately, it is also involved with many major disorders including Alzheimer’s and Parkinson’s diseases. Therefore, for both basic research and drug development, it is important to identify the sumoylation sites in proteins. Results: To address such a problem, we developed a predictor called pSumo-CD by incorporating the sequence-coupled information into the general pseudo amino acid composition (PseAAC) and introducing the covariance discriminant (CD) algorithm, in which a bias-adjustment term, which has the function to automatically adjust the errors caused by the bias due to the imbalance of training data, had been incorporated. Rigorous cross-validations indicated that the new predictor remarkably outperformed the existing state-of-the-art prediction method for the same purpose. Availability: For the convenience of most experimental scientists, a user-friendly web-server for pSumo-CD has been established at http://www.jci-bioinfo.cn/pSumo-CD, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved.
ردمد
:
1460-2059
اسم الدورية
:
Bioinformatics
المجلد
:
32
العدد
:
20
سنة النشر
:
1437 هـ
2016 م
نوع المقالة
:
مقالة علمية
تاريخ الاضافة على الموقع
:
Wednesday, July 12, 2017
الباحثون
اسم الباحث (عربي)
اسم الباحث (انجليزي)
نوع الباحث
المرتبة العلمية
البريد الالكتروني
Jianhua Jia
Jia, Jianhua
باحث
دكتوراه
Liuxia Zhang
Zhang, Liuxia
باحث
دكتوراه
Zi Liu
Liu, Zi
باحث
دكتوراه
Xuan Xiao
Xiao, Xuan
باحث
دكتوراه
Kuo-Chen Chou
Chou, Kuo-Chen
باحث
دكتوراه
الملفات
اسم الملف
النوع
الوصف
41979.pdf
pdf
الرجوع إلى صفحة الأبحاث