07-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Aminoglutethimide as an inducer of oxidative drug metabolism in the rat
Aminoglutethimide as an inducer of oxidative drug metabolism in the rat
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
There is some evidence that when aminoglutethimide is used in the treatment of patients with advanced breast cancer a clinically-significant degree of hepatic enzyme induction may occur. This activity of the drug has been investigated in female rats. After three daily oral doses (60 mg/kg) of aminoglutethimide, the hypnotic effect of hexobarbitone was significantly shortened and plasma levels of dicoumarol were lowered. This pretreatment regimen also diminished an estradiol-induced increase in uterine weight. Electron microscopy of liver from aminoglutethimide-treated rats revealed a proliferation of smooth endoplasmic reticulum. There were significant increases in the metabolism of 4-nitroanisole, dicoumarol and [14C]estradiol by the 10,000 × g supernatant of liver homogenates from aminoglutethimide-pretreated rats. In these animals, levels of hepatic microsomal protein, cytochrome P-450 and NADPH-cytochrome-C reductase were raised. The results are consistent with aminoglutethimide being a phenobarbitone-like inducer of the hepatic mixed-function oxidases
ISSN
:
0163-7258
Journal Name
:
Pharmacology & Therapeutics
Volume
:
33
Issue Number
:
1
Publishing Year
:
1407 AH
1987 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
Files
File Name
Type
Description
29439.pdf
pdf
Back To Researches Page