14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Global genetic variation of select opiate metabolism genes in self-reported healthy individuals
Global genetic variation of select opiate metabolism genes in self-reported healthy individuals
Document Language
:
English
Abstract
:
CYP2D6 is a key pharmacogene encoding an enzyme impacting poor, intermediate, extensive and ultrarapid phase I metabolism of many marketed drugs. The pharmacogenetics of opiate drug metabolism is particularly interesting due to the relatively high incidence of addiction and overdose. Recently, trans-acting opiate metabolism and analgesic response enzymes (UGT2B7, ABCB1, OPRM1 and COMT) have been incorporated into pharmacogenetic studies to generate more comprehensive metabolic profiles of patients. With use of massively parallel sequencing, it is possible to identify additional polymorphisms that fine tune, or redefine, previous pharmacogenetic findings, which typically rely on targeted approaches. The 1000 Genomes Project data were analyzed to describe population genetic variation and statistics for these five genes in self-reported healthy individuals in five global super- and 26 sub-populations. Findings on the variation of these genes in various populations expand baseline understanding of pharmacogenetically relevant polymorphisms for future studies of affected cohorts.
ISSN
:
1470-269X
Journal Name
:
The Pharmacogenomics Journal
Volume
:
1
Issue Number
:
1
Publishing Year
:
1438 AH
2017 AD
Article Type
:
Article
Added Date
:
Tuesday, May 16, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
FR Wendt
Wendt, FR
Investigator
Doctorate
G Pathak
Pathak, G
Researcher
Doctorate
A Sajantila
Sajantila, A
Researcher
Doctorate
R Chakraborty
Chakraborty, R
Researcher
Doctorate
B Budowle
Budowle, B
Researcher
Doctorate
Files
File Name
Type
Description
40761.pdf
pdf
Back To Researches Page