14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
Document Language
:
English
Abstract
:
Motivation: Sumoylation is a posttranslational modification (PTM) process, in which small ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protein. It is critical to many different biological processes such as replicating genome, expressing gene, localizing and stabilizing proteins; unfortunately, it is also involved with many major disorders including Alzheimer’s and Parkinson’s diseases. Therefore, for both basic research and drug development, it is important to identify the sumoylation sites in proteins. Results: To address such a problem, we developed a predictor called pSumo-CD by incorporating the sequence-coupled information into the general pseudo amino acid composition (PseAAC) and introducing the covariance discriminant (CD) algorithm, in which a bias-adjustment term, which has the function to automatically adjust the errors caused by the bias due to the imbalance of training data, had been incorporated. Rigorous cross-validations indicated that the new predictor remarkably outperformed the existing state-of-the-art prediction method for the same purpose. Availability: For the convenience of most experimental scientists, a user-friendly web-server for pSumo-CD has been established at http://www.jci-bioinfo.cn/pSumo-CD, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved.
ISSN
:
1460-2059
Journal Name
:
Bioinformatics
Volume
:
32
Issue Number
:
20
Publishing Year
:
1437 AH
2016 AD
Article Type
:
Article
Added Date
:
Wednesday, July 12, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Jianhua Jia
Jia, Jianhua
Researcher
Doctorate
Liuxia Zhang
Zhang, Liuxia
Researcher
Doctorate
Zi Liu
Liu, Zi
Researcher
Doctorate
Xuan Xiao
Xiao, Xuan
Researcher
Doctorate
Kuo-Chen Chou
Chou, Kuo-Chen
Researcher
Doctorate
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