14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
Document Language
:
English
Abstract
:
Protein remote homology detection is an important task in computational proteomics. Some computational methods have been proposed, which detect remote homology proteins based on different features and algorithms. As noted in previous studies, their predictive results are complementary to each other. Therefore, it is intriguing to explore whether these methods can be combined into one package so as to further enhance the performance power and application convenience. In view of this, we introduced a protein representation called profile-based pseudo protein sequence to extract the evolutionary information from the relevant profiles. Based on the concept of pseudo proteins, a new predictor, called “dRHP-PseRA”, was developed by combining four stateof- the-art predictors (PSI-BLAST, HHblits, Hmmer, and Coma) via the rank aggregation approach. Cross-validation tests on a SCOP benchmark dataset have demonstrated that the new predictor has remarkably outperformed any of the existing methods for the same purpose on ROC50 scores. Accordingly, it is anticipated that dRHP-PseRA holds very high potential to become a useful high throughput tool for detecting remote homology proteins. For the convenience of most experimental scientists, a web-server for dRHP-PseRA has been established at http://bioinformatics.hitsz.edu.cn/ dRHP-PseRA/.
ISSN
:
2045-2322
Journal Name
:
Scientific reports
Volume
:
6
Issue Number
:
1
Publishing Year
:
1437 AH
2016 AD
Article Type
:
Article
Added Date
:
Monday, July 17, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Junjie Chen
Chen, Junjie
Researcher
Doctorate
Ren Long
Long, Ren
Researcher
Doctorate
Xiao-long Wang
Wang, Xiao-long
Researcher
Doctorate
Bin Liu
Liu, Bin
Researcher
Doctorate
Kuo-Chen Chou
Chou, Kuo-Chen
Researcher
Doctorate
Files
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Type
Description
42006.pdf
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