14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
Three-dimensional reconstruction of fracture callus morphogenesis
Three-dimensional reconstruction of fracture callus morphogenesis
Document Language
:
English
Abstract
:
Rat and mouse femur and tibia fracture calluses were collected over various time increments of healing. Serial sections were produced at spatial segments across the fracture callus. Standard histological methods and in situ hybridization to col1a1 and col2a1 mRNAs were used to define areas of cartilage and bone formation as well as tissue areas undergoing remodeling. Computer-assisted reconstructions of histological sections were used to generate three-dimensional images of the spatial morphoge nesis of the fracture calluses. Endochondral bone formation occurred in an asymmetrical manner in both the femur and tibia, with cartilage tissues seen primarily proximal or distal to the fractures in the respective calluses of these bones. Remodeling of the calcified cartilage proceeded from the edges of the callus inward toward the fracture producing an inner-supporting trabecular structure over which a thin outer cortical shell forms. These data suggest that the specific developmental mechanisms that control the asymmetrical pattern of endochondral bone formation in fracture healing recapitulated the original asymmetry of development of a given bone because femur and tibia grow predominantly from their respective distal and proximal physis. These data further show that remodeling of the calcified cartilage produces a trabecular bone structure unique to fracture healing that provides the rapid regain in weight-bearing capacity to the injured bone.
ISSN
:
0
Journal Name
:
Journal of Histochemistry & Cytochemistry
Volume
:
54
Issue Number
:
11
Publishing Year
:
2006 AH
2006 AD
Article Type
:
Article
Added Date
:
Friday, January 4, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ياسر الخياري
Alkhiary, Yaser
Investigator
Doctorate
YALKHIARY@Kau.edu.sa
Files
File Name
Type
Description
Three-dimensional reconstruction of fracture callus morphogenesis.pdf
pdf
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