14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer
Document Language
:
English
Abstract
:
Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and early event almost uniquely observed in colorectal tumorigenesis. Alterations in the APC gene generate truncated gene products, leading to activation of the Wnt signaling pathway and deregulation of multiple other cellular processes. It has been a mystery why most patients with CRC retain a truncated APC protein, but accumulating evidence suggest that these C terminally truncated APC proteins may have gain of function properties beyond the well-established loss of tumor suppressive function. Here, we will review the evidence for both the loss of function and the gain of function of APC truncations and how together they contribute to CRC initiation and progression.
ISSN
:
0027-8874
Journal Name
:
JNCI: Journal of the National Cancer Institute
Volume
:
109
Issue Number
:
8
Publishing Year
:
1438 AH
2017 AD
Article Type
:
Article
Added Date
:
Tuesday, June 25, 2019
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Lu Zhang
Zhang, Lu
Researcher
Doctorate
Jerry W. Shay
Shay, Jerry W.
Investigator
Doctorate
jerry.shay@utsouthwestern.edu
Files
File Name
Type
Description
44535.pdf
pdf
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