14-12-2025
جامعة الملك عبدالعزيز
KING ABDULAZIZ UNIVERSITY
Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Fast STR allele identification with STRait Razor 3.0
Fast STR allele identification with STRait Razor 3.0
Document Language
:
English
Abstract
:
The short tandem repeat allele identification tool (STRait Razor), a program used to characterize the haplotypes of short tandem repeats (STRs) in massively parallel sequencing (MPS) data, was redesigned. STRait Razor v3.0 performs ∼660× faster allele identification than its previous version (v2s), a speedup that is largely due to a novel indexing strategy used to perform "fuzzy" (approximate) string matching of anchor sequences. Written in a portable compiled language, C++, STRait Razor v3.0 functions on all major operating systems including Microsoft Windows, and it has cross-platform multithreading support. In silico estimates of precision and accuracy of STRait Razor v3.0 were 100% in this evaluation and results were highly concordant with those of Strait Razor v2s. STRait Razor v3.0 adds several key features that simplify the haplotype reporting process, including simple filters to remove low frequency haplotypes as well as merging haplotypes within a locus encoded on opposite strands of the DNA molecule.
ISSN
:
1872-4973
Journal Name
:
Forensic Science International: Genetics
Volume
:
30
Issue Number
:
1
Publishing Year
:
1438 AH
2017 AD
Article Type
:
Article
Added Date
:
Wednesday, June 26, 2019
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
August E. Woerner
Woerner, August E.
Investigator
Doctorate
August.Woerner@unthsc.edu
Jonathan L. King
King, Jonathan L.
Researcher
Doctorate
Bruce Budowle
Budowle, Bruce
Researcher
Doctorate
Files
File Name
Type
Description
44538.pdf
pdf
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